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The General Data Protection Regulation provides you with rights of access, rectification, erasure, restriction, data portability, withdrawal and objection. If you believe that the processing of your data violates data protection law or if your rights under data protection law have been violated in any other way you can lodge a complaint with the supervisory authority. However, you may also contact us at any time using the contact details which can be found in our website’s ‘Contact’ section.
Data protection officer
You may contact our data protection officer by e-mail: firstname.lastname@example.org or by mail to the following address: PIQUR Therapeutics AG, Attn. Data protection officer, Hochbergerstrasse 60C, CH-4057 Basel, Switzerland
Date: 25 May 2018
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The material provided in this site is presented solely to improve public access to information about PIQUR Therapeutics AG.
PIQUR Therapeutics AG will make reasonable efforts to include accurate and current information, wherever possible, but makes no warranties or representations, expressed or implied, as to its accuracy or completeness. PIQUR Therapeutics AG will not be liable for any damages, including but not limited to special or consequential damages, that result from the use of, or the inability to use, the material contained in this site.
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Forward looking information
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PIQUR Therapeutics AG has no responsibility to update the forward-looking statements contained in this site to reflect events or circumstances occurring after the date of publication. You must not rely on this information for investment decisions.
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PIQUR Therapeutics AG
T +41 61 551 20 50
Highway A2 exit 1, along in direction Stücki/Kleinhüningen, you can drive up the ramp of the big grey building called Stücki Businesspark (next to the COOP gas station) and park right in front of the building or on the parking below.X
Bus no. 36 in direction Kleinhüningen, get off at bus-station «Hochbergerstrasse» (approx. 4 min.), follow driveway Hochbergerstrasse, after 150m on your right hand side you will see a big grey building called Stücki Business Park, go up the ramp and you find the entrance «C»X
Tram no. 2 in direction Eglisee, get off at tram-station «Basel Badischen Bahnhof» (approx. 10 min.), change and take bus no. 36 in direction Kleinhüningen, bus-stop «Hochbergerstrasse» (approx. 5 min.), follow driveway Hochbergerstrasse, after 150m on your right hand side you will see a big grey building called Stücki Business Park, go up the ramp and you find the entrance «C».X
PIQUR is located close to the centre of Basel on the north bank of the River Rhine, a few minutes from the borders of France and Germany. It is easily accessible by public transport from the two main railway stations and the airport.
The premises of PIQUR Therapeutics AG are located in the Technology Park Basel in the Stücki Business Park.X
PIQUR’s patent portfolio protects and covers a large area of lipid kinase and mTOR inhibitor patent space. PIQUR has created an intellectual property strategy that maximizes the protection of its technologies, knowhow and research areas of current and future interest. PIQUR’s differentiation against its peers is the outstanding industry expertise, the level of innovation with its unique, proprietary fragment and scaffold libraries and their best-in-class products with novel, balanced, dual-acting PI3K/mTOR inhibitors that fully address the given challenges, meeting therapeutic, tolerance and galenic needs.
One in every 2 men and one in every 3 women, living in the developed world, will develop cancer at some stage in their lives. In 2012, cancer accounted for 8 million deaths worldwide. Each cancer treatment remains a case-by-case battle, with a limited panel of therapeutic options available. Given the relatively small number of cancer treatments available today, the emergence of resistance usually means a poor prognosis. Thus, there is a tremendous need for new targeted therapies, based on new mechanisms of action and accompanied by a range of biomarker diagnostics for diagnosis, patient selection, therapy monitoring and follow up.
The PI3K-Akt-mTOR pathway is one of the three major cancer signalling pathways (Nature Rev. 2008). The PI3K/Akt/mTOR signalling pathway plays a critical role in the regulation of cancer cell growth, survival, and proliferation. The deregulation of this pathway is initiated by genetic mutations and amplifications, and is thought to be one of the most frequently mutated pathways in cancer. (Hennessy et al., 2005, Nat. Rev. Drug Discovery; Liu et al., 2009, Nat. Rev. Drug Discovery; Zoncu, R. et al., 2011, Nat. Rev. Mol. Cell Biol.).
PIQUR seeks to develop and market next generation medications for the treatment of cancer. To achieve this goal, PIQUR continues to expand on its strong product pipeline and has developed several proprietary methods for drug screening and identification
PIQUR has already identified a number of compounds that have desirable drug properties, both from a biological and a manufacturing perspective, forming the backbone of our pipeline.
PQR309: PIQUR’s lead compound, PQR309, is a novel, potent small molecule with strong, balanced pan-PI3K/mTOR selectivity. PQR309 compares favourably to current and clinically most advanced pan-PI3K inhibitors with respect to the off-target effects. PQR309 showed activity in different aggressive cancer cell lines inhibiting the PI3K pathway. In January 2014, PIQUR launched the clinical Phase 1 study in Europe with the PQR309 that was successfully concluded in Q2/2015. The initial results indicate that PQR309 is well-tolerated with no significant side effects and meets the primary endpoints of safety and tolerability. Furthermore, PQR309 demonstrated clear biologic activity and first promising signs of clinical activity in two advanced solid tumors patients with PI3K/mTOR alterations.
In addition to PQR309, PIQUR has several other compounds in preclinical development and late stage research in oncology, ophthalmology, dermatology and CNS disorders.